Acquired Bleeding Disordres Flashcards Preview

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Flashcards in Acquired Bleeding Disordres Deck (11)
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1

What are the major Acquired bleeding disorders?

1) Thrombocytopenia
2) Liver Failure
3) Drugs
4) Haemorrhagic Disease of Newborn

2

How would you spot someone who's thrombocytopenic?

Petechia
Ecchymosis
Mucosal bleeding
Rarely a CNS bleed

Then FBC

3

What are the major causes of thrombocytopenia?

Marrow failure or infiltration

ITP, DIC or hypersplenism

4

What could trigger Idiopathic Thrombocytopenic Purpura?

EBV
HIV
Lymphoma
Collagenosis
Quinine use

5

How do you diagnose ITP?

Patient presents with clinical history of thrombocytopenia i.e. bruising, petechia & mucosal bleeds

+ FBC showing thrombocytopenia

Very rarely need marrow tests

6

How do we treat ITP acutely?

Steroids & IV IgG

7

How do we manage ITP chronically?

Most cases are just one episode but if its long term:
- Platelet count good between episodes? Then leave it
- Platelet count consistently low? --> Thombopoietin Analogues

8

How does liver disease contribute to bleeding?

Liver produces a lot of coagulation factors + Fibrinogen + Thrombopoietin
So someone with chronic liver disease will produce less --> Excess of both bleeding

9

Where do people with liver disease tend to bleed from?

Varices

10

Drugs cause most cases of acquired bleeding disorder, what ones particularly?

Warfarin
Heparins
Aspirin
Anti-platelets
DOACs

11

What is haemorrhagic disease of a newborn?

Babies with immature coagulation system + Vit K deficiency ---> Fatal Haemorrhage

Very rare in the western world as we give newborns a Vit K inj