Acetaminophen Flashcards Preview

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Flashcards in Acetaminophen Deck (11)
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1
Q

What is the MOA of acetaminophen?

A

Central anti-prostaglandin effect (very LITTLE peripheral nerve activity):

  • antipyretic
  • pain reduced via blockade of: NMDA receptor activation in CNS; AND Substance P in the SC!
2
Q

What is the class of acetaminophen?

A

Non-opioid Analgesic

3
Q

What does Acetaminophen LACK, which is why it is NOT a true NSAID? This makes it a good choice for?

A
lacks peripheral activity- weak anti-inflammatory action
Good choice for :
-PUD
-Pediatric patients
-Pts who need well fxning platelets
-Preggers safe
4
Q

Tell me about the potency of acetaminophen w/r/t ASA

A

Similar potency as ASA (in single analgesic doses, has same time-effect curve)

5
Q

What is the dose of acetaminophen?

A

325-650mg Q4-6 hours

6
Q

Howis acetaminophen metabolized?

A

conjugated and hydroxylated to inactive metabolites; very little excreted unchanged by the kidneys

7
Q

What is the IV dose of acetaminophen?

A

1000mg IV (or 1gram) over 15min Q4-6 hours

8
Q

What is the max dose IV of acetaminophen?

A

4 grams! can get liver and kidney damage

9
Q

What is a major side effect of acetaminophen and renal?

A

renal toxicity:

  • renal papillary accumulation of metabolites can cause renal cell necrosis
  • may be a development of ESRD
  • but NSAIDS are higher risk of renal tox!
10
Q

What can overdose of acetaminophen cause?

A

serious or fatal HEPATIC INJURY

  • liver can only metabolize a limited amt of the hapatotoxic metabolite N-acetyl-p-benzoquinone with Glutathione
  • when glutathione outnumbered by OD of acetaminophen hepatic injury occurs
  • safe dose EVEN LOWER in ETOH
  • increased tox with Isoniazid
11
Q

What medication can you give in an overdose of acetaminophen? What are the time constraints?

A

-Acetylcysteine can substitute for glutathione and prevent hepatic injury if given within 8 hours of OD