3.3.3 Serum Sickness Flashcards Preview

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Flashcards in 3.3.3 Serum Sickness Deck (17)
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1
Q

How does C1q measure measure IC?

A

Radiolabeled C1q is used to bind to circulating immune complexes

2
Q

What does a reduced CH50 indicate?

A

Reduced levels of classical and/or MAC components

3
Q

In a person with an active immune response going on, why would C3 and C4 levels be reduced?

A

The production of immune complexes may reduce serum C3 and C4 levels

4
Q

What is a chimeric Ab?

A

A chimeric antibody (cAb) is an antibody made by fusing the antigen binding region (variable domains of the heavy and light chains, VH and VL ) from one species like a mouse, with the constant domain (effector region) from another species such as a rabbit.

5
Q

On what cells is CD20 most present?

A

Found only on Pre- and mature B cells

6
Q

Serum sickness is an example of what type of hypersensitivity?

A

Type III

7
Q

What is the immediate course of action to follow with a patient taking Rituximab that subsequently develops serum sickness?

A

Take them off of it and maybe give steroids

8
Q

What happens to deposited immune complexes in serum sickness?

A

They are removed by phagocytes

9
Q

What is serum sickness?

A

It is a type III hypersensitivity reaction, in which the person has developed an immune response against some type of therapy (Drugs, Mab, etc.)

10
Q

What is being used to overcome diminish the possibility of serum sickness?

A

Chimeric antibodies

11
Q

What is an arthus reaction?

A

Localized Type III hypersensitivity reaction

12
Q

Chron’s is what type of hs reaction?

A

Type IV

13
Q

Lupus is what type of hs reaction?

A

Type III

14
Q

Poison ivy is what type of hs reaction?

A

Type IV

15
Q

Eczema is what type of hs reaction?

A

Type I

16
Q

Sarcoidosis is what type of hs reaction?

A

Type IV

17
Q

Anaphylactic shock is caused by what type of hs reaction?

A

Type I

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