26. Pharmacology IV (Classifications of drugs in ANS) Flashcards Preview

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Flashcards in 26. Pharmacology IV (Classifications of drugs in ANS) Deck (148)
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1

“Analeptics”

Stimulants

2

Drugs used to increase nerve activity in the CNS
✔️ reverses CNS depressant effects
🔸 elevates adnergic nt
🔸stimulates release of NOREPI

Stimulants

3

BQ: “Most toxic drug”

Strychnine

4

Amphetamines
Methylphenidate
Phendimethrazine
Xanthines
Strychnine
- are examples of what drugs?

Stimulants or Analeptics

5

BQ: Xanthines
(Found in: Teas, coffee, colas, cocoa)

Caffeine
Theophylline
Theobromine

6

BQ: What xanthines are used to treat Asthma?

Theophylline
Theobromine

7

BQ: the only OTC stimulant

Caffeine

8

BQ: Stimulants can be used to treat: (“PONDA”) 🐼

(“PONDA”) 🐼🐼🐼
Parkinson’s disease
Obesity
Narcolepsy
Depression
Attention deficit hyperactive disorder (ADHD)

9

Increase daytime sleepiness
(Can be tx by stimulants)

Narcolepsy

10

Disease caused by degeneration of dopamine producing cells in the brain

Parkinson’s disease

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Site of dopamine production

Substantia NIGRA

✔️ Parkinson’s disease: Degeneration of substantia nigra

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Basal ganglia degeneration

Huntington’s disease

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Drug of choice for Parkinsonism

L-DOPA

🔸 Boards: (✔️anticholinergic)

14

Other drugs for Parkinsonism:
✅ Increases dopamine
-
-
-
✅Anticholinergic
- Major :
- Minor/slight:

Other drugs for Parkinsonism:
✅ Increases dopamine
- L-Dopa (DOC!✨)
- MAO-I
- Stimulants

✅Anticholinergic
- Major : Belladonna alkaloids (Atropine/Scopolamine)
- Minor/slight: “DiTriBeAM”

15

BQ: What are the drugs that causes Parkinsonism-like symptoms?

1st generation antipsychotic agents

16

Division of the Autonomic nervous system regulated mainly by ACETYLCHOLINE

✅ REST AND DIGEST 💆🏼‍♀️🍌🍒🍉

Parasympathetic nervous system

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Division of ANS regulated mainly by NOREPINEPHRINE

✅ Fight 👊🏻 or Flight ✈️
- Stress and Emergency situation

Sympathetic nervous system

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Neurons before the ganglion

Pre ganglionic neurons

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Neurons after the ganglion

Post ganglionic neuron

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Neurons releasing ACH

Cholinergic neurons

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Cholinergic neurons:

1. Motor neurons in NMJ
2. All pregang neurons (symp/para)
3. Postgang of Parasymp
4. Postgang of Sweat glands(symp*)

22

Nicotinic receptors are found:

Skeletal muscle
All Postganglionic neurons
Chromaffin cells

23

Muscarinic receptors are found:

All effector organs of parasymp
Sweat glands

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Neurons releasing Norepinephrine

Adrenergic neuron

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Adrenergic neuron found on:

Sympathetic post ganglionic neurons

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Adrenergic receptors are found:

All effector organs of Sympathetic
(EXCEPT: SWEAT GLANDS 🙅‍♀️)

27

BQ: Most numerous Adrenergic receptor seen in the BLOOD VESSEL

Alpha 1

28

Effect of Alpha 1

BV: Vasoconstriction
BP: ⬆️

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Effect of Alpha 2:

Vasodilation

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Effect of Beta 1:
❤️ :
kidney:

❤️
- Inotropic : ⬆️ Force of contraction
- Chronotropic : ⬆️ Heart rate

KIdney: ⬇️ function