25. Pharmacology III (Steroidal Drugs-Alcohol) Flashcards Preview

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Flashcards in 25. Pharmacology III (Steroidal Drugs-Alcohol) Deck (49)
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1

Drugs with suffix of -sone and -lone

Steroidal drugs

2

Mechanism of action of STEROIDS: Inhibits what enzyme?

Inhibits phospholipase A2❌
Resulting to decrease Arachidonic acid⬇️

3

*Pharmacologic uses of steroids:

✅Anti-inflammatory- ❌prostaglandins/prostacyclins

✅ Immunosuppressant - induces "Lympholysis" (sinisira yung lymphocytes) - used during AUTOIMMUNE DISEASES

✅ Prevents graft rejection and prosthetic rejection
- ex. End stage renal disease: kidney transplant=para hindi iattack ng immune system ung kidney grafts)

✅Treatment for Addison's disease (⬇️cortisol)
- give corticosteroids bec it is similar to cortisol

4

BQ: rx app of corticosteroids

Bilateral mandibular radiolucency

5

Corticosteroids are used for treatment of Addison's disease; but it may cause Addison's disease for normal patients (adrenal cortex atrophy)

1. Zona fasciculata waits for "ACTH" coming from Anterior pituitary gland before secreting cortisol
2. Ant pit gland receives "CRH" from the Hypothalamus
3. If patients take CORTICOSTEROIDS which mimics cortisol = iniisip ng hypothalamus ⬆️cortisol levels so i-⬇️ CRH; ⬇️ACTH; ⬇️cortisol = ADDISON'S DISEASE

6

BQ: Before surgical extraction, what will you do if the patient is under long term steroidal therapy

"Double the dose"

7

Antipsychotic drugs are aka: (3)

Major tranquilizers
Neuroleptic agents
Hallucinogens

8

Drugs that affect mood and mental process

Antipsychotic drugs

9

Type of psychotic disorders caused by EXCESSIVE DOPAMINE LEVELS

Schizophrenia

10

Deficient dopamine levels ⬇️

Parkinson's

11

*"potent D2" dopamine receptor antagonist than D1

First generation antipsychotic drugs

12

Adverse effect of First generation antipsychotic drugs

Extra pyramidal syndrome or "Tardive dyskinesia" or "Parkinsonism like symptoms"

13

BQ: First generation antipsychotics drugs (pinapaexcept sa boards)

Phenothiazines - (Chlorpromazine)
Butyrophenones - (droperidol)
Thioxanthenes

14

"Weak D2" receptor antagonist

Second generation antipsychotic drugs

15

Adv of second generation vs first gen antipsychotic drugs

No tardive dyskinesia in 2nd gen
(ex. clozapine)

16

"bipolar disorder"

Manic-Depressive syndrome

17

DOC for Manic depressive syndrome/ Bipolar disorder:

Antipsychotic drug: "LITHIUM ION"✅

(Pag mania lang nacocontrol ng lithium ion add antidepressant: "TCA" (amitriptyline)

18

BQ: most common TCA: for depression

Amitriptyline

19

Patients presents with "Tic"
Tic:
- habitual spasmodic muscle contractions
- uttering words

Tourette's syndrome

20

Tx for tourette's syndrome

Antipsychotics
- (depresses CNS:"major tranquilizers")

21

Major tranquilizers

Antipsychotics = MAJOR TRANQUILIZERS

22

Minor tranquilizers

Antiseizure/Anticonvulsants

23

BQ: drugs with Slight anticholinergic effects

Diphenhydramine hcl
Tricyclic antidepressants
Benzodiazipines
Antipsychotics
Meperidine

24

"Feeling of inner restlessness"
- paradoxical Side effect of antipsychotics (dapat pinapakalma)

Akathisia

25

Lithium ion is doc for

Manic depressive syndrome or Bipolar disorder

26

BQ: what is the antipsychotic drug with antihypertensive properties?

Reserpine

27

BQ: Which of the ffg drugs can be used to treat parkinsonism-like symptoms?
A. Anticholinergic
B. Narcotics
C. Anti depressant
D. None of the above

Anticholinergics!!!!!

(doc for parkinsons=LEVA DOPA✅
*Other drugs that can be used:
- stimulants
- MAO-I
- anticholinergics✨📌

28

BQ: Drugs used for Neuroleptic Analgesia

Narcotic
Butyrophenones
Nitrous oxide (N2O2) "laughing gas"

29

Nervous disorder characterized by a state of uneasiness and apprehension, typically with panic attacks

Anxiety

30

"anxiolytics"

Anti-anxiety drugs