24. Pharmacology: Part II (Narcotics-Non narcotics) Flashcards Preview

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Flashcards in 24. Pharmacology: Part II (Narcotics-Non narcotics) Deck (120)
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1

Gold standard of narcotics

Morphine

2

Narcotics are derived from what type of plant?

Poppy plant : Papaver somniferum

3

Narcotics are also known as (3Os)

Opioids
Opiates
Opium

4

3 receptors of narcotics

Mu
Kappa
Delta

5

Drugs with morphine-like properties that acts in CNS

Morphine

6

Opioid receptors (mu kappa delta) nakikita sa: Limbic system (emotion center)

* Narcotics = controls pain and reaction to pain
: (because inaalter ung limbic system)

Limbic system:
🔺Hippocampus - memory center
🔺Amygdala - resp for fear,anger, arousal; (almond shape)
🔺substantia nigra - dopamine production
🔺basal ganglia - voluntary motor movts

7

Most common side effect of narcotics

Nausea
- (Area Postrema)

8

Part of nervous system that controls
✅cough reflex
✅gastric motility
📌 action of narcotics???

Solitary nuclei - gag,cough reflex..

📌 Narcotics suppresses cough reflex

9

Narcotics that suppresses Cough reflex

"anti tussive" (Dextromethorphan)

10

Drug taken to inhibit gastric motility

Loperamide (Diatabs)

11

BQ: "gate" in gate control theory

Substantia gelatinosa of Rolando

12

Most accepted theory for pain;
- painful stimulus: gate opens
- non painful: gates closes

Gate control theory

13

BQ: What are the endogenous opioids produced by our body?

Enkephalins
Endorphins

14

BQ: Narcotic agents blocks pain in the "peripheral" nervous system. True/False?

False - blocks pain in CNS!

15

BQ: What is the combination of Diphenoxylate and Atropine

Lomotil

16

Induces gastric motility

Laxatives (Bisacodyl)

17

Therapeutic effects of Narcotics: (ASEE)

Analgesia
Euphoria
Sedation
Eliminates cough

18

BQ: what kind of drug is Guaifenesin?

Expectorant

19

Most common side effect of narcotics

Nausea

20

BQ: drug that puts patient in "trans like state"

Ketamine

21

Adverse effect of narcotics which is opposite of euphoria

Dysphoria

22

Most serious side effect of narcotics

Respiratory depression

23

BQ: Morphine Triad (due to overdose)

Miosis (pupillary constriction:pinpoint)
Respiratory depression
Coma

24

BQ: What are the components of Neuroleptic analgesia? (Anesthetic technique that puts px in stage 1 anesthesia)

1. neuroleptic agents/antipsychotics
- Butyrophenones : (induces hallucinations)
2. Narcotics
3. Nitrous oxide (optional)

25

BQ: What is the drug that causes "dissociative" anesthesia? / "trans like state"

Ketamine
- conscious mind separated from body
- "trans like state"

26

BQ: What type of drugs are contraindicated to glaucoma

Diazepam
Anticholinergic drugs

27

Ano nakikita ng patient na may glaucoma?

"Tunnel vision"

28

BQ: type of NARCOTIC drug contraindicated to glaucoma?

Meperidine (may slight anticholinergic effect)

29

BQ: Drug contraindicated to glaucoma
choices: one of "DiTriBeAM" bec it has slight anticholinergic

Is Diphenhydramine contraindicated to glaucoma? Yes. (All DiTriBeAM sa boards)

30

Drug used for severe orofacial pain

Codeine
- "prodrug" : converted to morphine
- orally
- common na ginagamit sa dental: bec low drug dependence