23. Pharmacology: Part 1 (-Anticonvulsants) Flashcards Preview

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1

Branch of medicine concerned with the USES, EFFECTS, and MODES OF ACTION of drugs

Pharmacology

2

Branch of pharmacology concerned with the EFFECTS OF DRUGS and the MECHANISM of their action ("action of drug on the body")

Pharmacodynamics

3

Branch of pharmacology concerned with the MOVEMENT OF DRUGS within the body ("action of body to the drug")

Pharmacokinetics

4

Pharmacokinetics steps: "ADME"

Absorption
Distribution
Metabolism
Excretion

5

Main site of absorption in the body

Jejunum of small intestine

6

BQ: Primary solubility of drug to be absorbed?
(Form of drug that is EASY TO ABSORB)

Lipid soluble form

7

Major site of metabolism

Liver

8

converts drugs into water soluble form to easily excreted by the kidney

Liver

9

Form of drug that is EASY to EXCRETE

Water soluble

10

Major site of excretion

Kidney

11

Study of drug's harmful effects

Toxicology

12

General rule: Kailan nagiging toxic yung drug?

Pag na-"overdose"

13

Has "Adsorption" property (nagsstick sakanya yung toxins; diretso sa excretory system) to prevents ORALLY taken drugs TOXICITY

Activated charcoal

14

INDUCES VOMITING (emetic) ; can be used pag nasa GIT pa yung drugs na tinake para di na pumunta sa circulatory system

Syrup of Ipecac

15

BQ: It is the "accumulation of drug" because it cannot be excreted by the body?

Cumulation

16

"Cumulation" or accumulation of drug in the body is associated with what organ damage?

1. Liver damage - clearance rate: ⬇️ (marereduce yung nacconvert na Lipid soluble ➡️ WATER soluble)

2. Kidney damage - Normal yung liver:nacoconvert yung drug into water soluble BUT hard to excrete!

17

BQ: Drugs contraindicated for GLAUCOMA?

Diazepam
Anticholinergic drugs

18

BQ: What is the most common allergenic drug?

Penicillin

19

BQ: Drugs SAFE FOR PREGNANCY

Local anesthetics : lidocaine
Analgesics : biogesic
Sedative-Hypnotics
*AMOXICILLIN (safe!)

20

BQ: study of DAMAGE TO FETUS during development

Teratology

21

Most critical period of development of fetus?

1st trimester: organogenesis

22

Examples of Teratogenic drugs

1. Tetracycline :tooth discoloration (til 8y/o)
2. Thalidomide
- An anti cancer drug {no effect sa pregnant rats=no effect ; clinical trial=dysplastic tissues: bata kulang body parts}

23

BQ: study of drug DOSAGE

Posology

24

Process of DRUG UPTAKE from the site of administration towards the bloodstream

Absorption

25

"Enteral"

Oral
Rectal

26

"Parenteral" - uses needle

IV
IM
Intradermal
Subcutaneous
Intrathecal

27

Most common route; easy to administer

Oral route

28

Suppositories

Rectal

29

Route with 100% bioavailability; bypasses the first pass effect; "TOTAL ABSORPTION"
- (100ml inject = 100ml circulatory system)

Intravenous

30

Term: Dose ng drug na nakakarating sa circulatory system

Bioavailability