Describe the general properties of polyomavirinae.
What are the different polyomaviruses that infect human?
Describe the structure and genomic organization of polyomavirues.
Describe the difference between the early and late gene products of the polyomaviruses.
Describe the roles of the large and small T-antigens.
What is the replication cycle of the polyomaviruses?
Important: Describe the role of the T-antigen and its role in the p53 and Rb tumor suppressor pathways.
Describe the general characteristics of the JC virus.
Describ the pathogenesis of the JC/BK virus.
Describe the relationship between the JC Virus and PML.
JC virus can lead to PML in immunocompromised patients - Demyelination of the CNS caused by destruction of the oligodendrocytes
What are these images of?
Describe the characteristics of the BK virus.
What is PVAN?
Describe the treatments for JC/BK virus.
Why were papilloma viruses initially so difficult to create a vaccine against?
Papilloma virus resistend culturing in cell culture systems
What are the characteristics of HPV?
Describe the structure and genome of the papillomaviruses.
Describe the HPV replication cycle.
Important: What are the mechanisms of evasion by HPV?
What is condyloma acuminata?
Caused by HPV 6 and 11
What is the common wart?
Caused by HPV 2 and 4
What are plantar warts.
Wart on sole of foot
HPV 1, 2, and 4
How can immunosuppression affect size of warts?
Patients may be plagued with many large warts
Describe the progression of HPV in relation to CIN 1, 2 and 3
Integration of HPV into host genome results in?
Inactivation of E2
Describe the roles of the E1 and E2 proteins.
What is the role of the E5 protein.
What is the role of the E6 protein?
Describe the role of the E7 protein.
Describe the HPV vaccine.