1.5.3 Anti-Inflammatories Flashcards Preview

Inflammation and Immunity > 1.5.3 Anti-Inflammatories > Flashcards

Flashcards in 1.5.3 Anti-Inflammatories Deck (21)
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1
Q

Glucocorticoids are derivatives of what?

A

Cortisol

2
Q

NSAIDs are inhibitors of?

A

COX

3
Q

Glucocorticoids are used when inflammation is associated to what?

A

Allergic or immune responses

4
Q

NSAIDs are used for what?

A

To reduce inflammation, treat pain and reduce fevers

5
Q

Glucocorticoids have an issue with what?

A

raising glucose levels

6
Q

Immunosuppression would call for a glucocorticoid or a NSAID?

A

glucocorticoid

7
Q

When glucocorticoids are given for more than 2-4 weeks what happens?

A

there is feedback suppression of the hypothalamic-pituitary-adrenal (HPA) axis. The longer the drugs are given, the more prolonged the suppression. This is the main reason that glucocorticoids are tapered off whenever long term therapy is used. The body’s normal response to physiologic stress is to release higher than normal amounts of cortisol and epinephrine from the adrenal gland.

8
Q

Ketorlac and asprin are inhibitors of what?

A

COX-1

9
Q

Prednisone and dexamethasone are what?

A

Synthetic glucocorticoid drugs

10
Q

celecoxib and diclofenac inhibit what?

A

COX-2

11
Q

What can be said about ibuprofen and naproxen?

A

These inhibit both classes evenly

12
Q

COX-2 inhibitors tend to have what effect?

A

typically the thrombotic and hypertensive cardiovascular adverse reactions (even in “healthy” patients) are more common with more selective COX-2 blockade

13
Q

GI complications are associated with what inhibitors?

A

COX-1 inhibitors

14
Q

Inhibition of platelet function and bleeding is a common side effect of what inhibitors?

A

COX-1

15
Q

cardiovascular events associated with the COX?-selective inhibitors (i.e. –coxibs) has been attributed to the promotion of platelet aggregation

A

COX-2

16
Q

Asprin has effects of what COX?

A

COX-1

17
Q

High doses of acetaminophen can lead to what?

A

Hepatotoxicity

18
Q

Consumption of what would cause a physician to lower the prescribed dose of acetaminophen to a patient?

A

Ethanol

19
Q
A

Acetaminophen

20
Q
A

Celecoxib, because COX-1 inhibitors can inhibit platelet function and cause further bleeding. This patient is already on an anti-coagulant, and we would not want to exacerbate the patients condition.

21
Q
A

Acetaminophen

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