13: Autoimmune and HIV - Feilmeier Flashcards

1
Q

are autoimmune diseases secondary to tissue damage?

A

NO - clinical or experimental evidence that such a reaction is not secondary to tissue damage but is of primary pathogenetic significance

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2
Q

what is dermatomyositis?

A

inflammatory m disease, resulting from immune-mediated intramuscular vessel injury
- common present with proximal m weakness

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3
Q

gottron’s sign or papules

A
  • smooth, flat-topped, violaceous to red lesions on knuckles
  • ** pathognomonic for dermatomyositis
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4
Q

dermal lesions dermatomyositis

A
  • helitrope erythema of the eyelids
  • gottron’s sign or papules
  • photosensitive
  • poikiloderma
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5
Q

rheumatoid arthritis produces a proliferative __________ at the joints

A

synovitis

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6
Q

key cutaneous manifestation rheumatoid arthritis

A

subcutaneous nodules

- usually present over joints and may or may not be symptomativ

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7
Q

CREST syndrome

A
calcinosis
raynaud phenomenon
esophageal dysmotility
sclerodactyly
telangiectasia
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8
Q

what is scleroderma/systemic sclerosis

A

excessive deposition of collagen/fibrosis secondary to abnormal activation of the immmune system due to unknown causes

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9
Q

dermal manifestations of scleroderma

A

generalized - raynauds, pufffiness/edema, narrow fingers and toes

localized - central thickened ivory with peripheral hyperpigmentation, hair loss, anhydrosis

linear - band like induration that might cause contracture

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10
Q

Sm antigen and antibodies against double stranded DNA

A

systemic lupus erythema SLE

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11
Q

butterfly rash

A

SLE

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12
Q

what do you see in nails of SLE patient

A

nail folds typically show telangiectasis

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13
Q

+ nikolsky sign

A
  • ability to produce a blister by rubbing skin adjacent to a natural blister
  • indicates pemphigus group
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14
Q

pemphigus group blistering diseases (superficial)

A

+ nikolsky sign

+ acantholysis ( loss of intercellular connections, such as desmosomes, resulting in loss of cohesion b/w keratinocytes)

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15
Q
  • nikolsky sign
A

pemphigoid group blistering disease (separation at basement membrane level)

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16
Q

what skin disorder is associated with celiac disease?

A

dermatitis herpetiforms/ duhring’s disease

- grouped blisters appear on erythematmous base

17
Q

most common cutaneous bacterial infection in the HIV pt

A

staph aureus

18
Q

presents as an eroded or superficially ulcerated lesion with an adherent crust. purulent material present under crust

A

ecthyma

19
Q

fleshy, friable, protuberant papules-nodules. bleed easily.

*resemble pyogenic granulomas

A

bacillary angiomatosis (caused by bartonella)

20
Q

CD4 levels and molluscum contagiosum

A

less than 200 - lesions tend to proliferate

less than 50 - extensive infection involving the mucosal surfaces, lips, or conjunctiva

21
Q

tinea starting _______ should send off immunocompromised warning flags

A

proximally , normally starts distally

22
Q

organism of tinea infection nail plate

A

trichophyton rubrum

23
Q

may be associated with palmoplantar keratoderma

A

syphilis

24
Q

initially appears as red to brown flat macules, papules, nodules or tumors

A

kaposi sarcoma [ tumor of mesenchymal cells involving the skin and other organs at times ]

25
Q

4 subtypes of kaposi sarcoma

A

classic KS
african KS
KS in iatrogenically immunosuppressed
AIDS-related KS

26
Q

diagnosis kaposi sarcoma

A

biopsy