046 Metastatic disease and oncology drug development Flashcards Preview

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Flashcards in 046 Metastatic disease and oncology drug development Deck (3)
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1
Q

What is E-cadherin?

A

responsible for cell to cell adhesion to help assemble and maintain epithelial sheets.

2
Q

What does N-cadherin do?

A

promotes migration of cells

3
Q

How do PARP inhibitors work?

A
  1. PARP inhibitors increase single strand breaks
  2. This forms toxic dna double strand breaks
  3. In BRCA1/2 mutated cells, they lose any ability to repair
  4. Normal cells, BRCA allows for HR function so DNA repaired.