042 Haemopoiesis and haematological malignacies Flashcards Preview

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Flashcards in 042 Haemopoiesis and haematological malignacies Deck (15)
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1
Q

Which has a better cure rate, hodgkins or non-hodgkins lymphoma?

A

hodgkins lymphoma

2
Q

What does the cytokine erythropoietin stimulate?

A

anti-apoptosis of red blood cells and increase in RBC progenitors.

3
Q

What does the cytokine G-CSF stimulate

A

neutrophil half life extension during infections

4
Q

How do you cure CML?

A

Complete replacement of haematopoietic cells with HLA match donor

5
Q

What does philadelphia chromosome result in?

A

increased proliferation

decreased apoptosis

6
Q

What does PML-RARa result in?

A

Differentiation block

7
Q

What does IgH-Myc result in?

A

Increase proliferation

8
Q

What does IgH-Bcl2 result in?

A

decrease apoptosis

9
Q

WHich B cell lymphoma responds better to cytotoxics?

A

Burkitss lymphoma

10
Q

Describe the Ras pathway

A

RAS - GDP is inactive
SOS replacing GDP with GTP acitvates it
Promote proliferation
GTPases such as NF-1 changes GTP-Ras back to GDP-Ras

11
Q

How does loss of NF1 result in AML or ALL?

A

No negative feedback on the Ras proliferation pathway

12
Q

What would you treat a woman who has CML with if she is at child bearing age?

A

inteferon alpha (antiproliferative cytokine)

13
Q

Which chromosome is the lambda light chain located on?

A

Chromosome 22

14
Q

Which chromosome is the kappa light chain located on?

A

Chromosome 2

15
Q

What are BH3 mimetics?

A

Small molecules that activate apoptosis. inhibits BCl2, which leads to apoptosis.