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Question 1

What are diphenydramine, chloropheniramine, and meclizine?

Answer 1

first gen antihistamines

(cross BBB and cause sedation)

Question 2

1. What are cetrizine, loratidine, and fexofenadine?

Answer 2

1. 2nd gen antihistamines

(don’t cause drowsiness)

Question 3

COX 1 vs COX 2

1. which one is inducible?
2. which one causes inflammation?
3. what does a good cox inhibitor do?

Answer 3

1. 2 (1 is constitutively expressed)
2. 2 (by making prostanoids)
3. selectively inhibits 2